PICO (T) Questions and Evidence-Based Approach PICO (T) is a renowned tool for Evidence-Based Practice (EBP). It signifies population, intervention, comparison, outcome, and time. Analyzing a research question into these components styles identification and evaluation of appropriate EBP (Kloda et al., 2020). A stroke is defined as an acute, focal neurological disorder that is triggered by a vascular injury that can cause either central nervous system bleeding or infarction. It is not a single medical condition. It can be caused by various risk factors, conditions, and disease processes (Murphy & Werring, 2020). This assessment will concentrate on a PICO(T) question related to the issue of stroke. Exploration of Practice Issue The epidemiological landscape of stroke in the US has changed. With more than 140,000 fatalities a year, it is still the fifth top cause of death. Stroke has a significant financial effect on the healthcare system, with annual costs in the US achieving $34 billion (Khan et al., 2021). It is the leading cause of permanent physical impairment in adults. The most essential variable risk indicator for stroke is hypertension, and its effect depends on the subtypes of stroke (Murphy & Werring, 2020). PICO(T) Question Ischaemic stroke individuals (P) use antihypertensive medications(I), compared to patients not taking antihypertensive medicines(C), reduce the rate of recurrent stroke (O), over 12 month period (T)? Population (P) Ischaemic stroke individuals Intervention (I) Antihypertensive medications Comparison (C) Patient not using antihypertensive medicines Outcome (O) Reduce incidence of recurrent stroke Time (T) 12-month Benefits of the PICO(T) Approach The PICO(T) approach is widely popular in the scientific nursing and healthcare sciences. Substantial evidence supports its effectiveness in establishing guidelines and boosting search efficiency (Schiavenato & Chu, 2021). Standard guidelines based on hypertension management are essential in the prevention of stroke. It aids in distinguishing and evaluating evidence-based research for stroke patients. The PICO(T) approach improves the overall caliber of research by boosting the credibility and strength of the evidence collected (Kloda et al. (2020). In the research findings of Jørgensen et al., (2022), many people with stroke had visited and diagnosed with hypertension. People using antihypertensive medicines at the time of the stroke showed a reduction in the risk of stroke. Sources of Evidence It is essential to consider sources’ quality, validity, and applicability when assessing the PICO(T) question. PICO(T) must be solved effectively by consulting various sources, such as databases and peer-reviewed publications. Reputable hospitals may contribute to comprehensive scrutiny of the research question (Kattie, 2021). A substantial rise in blood pressure is the most public clinical symbol of Acute Ischaemic Stroke (AIS).To offer helpful evidence, RCTs compare antihypertensive medications with no-lowering BP medicines in stroke patients. These findings can evaluate the effect of treatment on stroke individuals over a stated period (Whelton et al., 2018). People with previous ischaemic strokes are advised to take antihypertensive medicines to reduce recurrent stroke (Dawson et al., 2022). These studies can include data from multiple sources to assess the broad outcome on the brain (García-Rudolph et al., 2019). Evidence-based proposals for treating stroke can be found by studying reputable clinical practice guidelines. The American Heart Association’s (AHA) suggestions for decreasing stroke risks frequently integrate the most recent research. These guidelines provide a current set of suggestions in one document for clinicians caring for adult patients who have experienced an acute arterial ischemic stroke. Hospital administrators, doctors, allied health professionals, and prehospital care providers are among the target audience members (Powers set al., 2019). Rationale The risk of ischemic stroke is significantly affected by blood pressure (BP), and it has been shown that decreasing blood pressure to less than 150/90 mmHg lowers the rate of stroke. It is the top factor to know that controlling blood pressure in hypertensive emergencies is directly linked to brain damage, such as acute ischemic stroke (Wajngarten & Silva, 2019). Significant cardiovascular health difficulties that can cause morbidity and mortality include cardiac arrest and stroke. The PICO(T) question allows the assessment of interventions for short-term and long-term effects on stroke patients. Findings from Sources of Evidence One of the main risks of stroke is high blood pressure. When systolic blood pressure rises doubles than diastolic, it increases the risk of stroke (Wajngarten & Silva, 2019). Antihypertensive medication lowere